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Forsyth Medical Center


Novant Health Clinical Research provides access to a variety of cardiac research studies. 

Study Name/Number: PROACT
(This study is recruiting participants.)

Title: PROACT: Prospective Randomized On-X valve Anticoagulation Clinical Trial (PROACT) Clinical Pathway

Investigator: David Duncan, MD

Purpose: The purpose of the study is to show that various patient groups with the On-X Valve can be maintained safely on lower doses of Coumadin® or on antiplatelet drugs only rather than the standard dose of Coumadin and aspirin presently recommended by ACC/AHA or ACCP professional societies.

  • Patients requiring isolated aortic valve replacement (AVR), or isolated mitral valve replacement (MVR).
  • AVR patients receiving low dose or antiplatelet-only anticoagulation
  • Concomitant cardiac surgery
  • Adult patients age 18 to age 70
  • Genders eligible for study: both
  • Accepts healthy volunteers: no

Contact Information:
    Kevin Colston

Link to the current record »